Because myelination begins in earnest right after birth, it came up as a suspect at this point. This pointed to a problem with the peripheral nervous system. In parallel, the scientists knocked down BACE in zebra fish and noticed a movement phenotype, where the fish no longer swam away as normal ones do in response to a shock. “That gave us the idea that something must happen functionally after birth with BACE.” “It was a difference like night and day and night,” recalled Haass. They saw no BACE expression in adult mice, but sky-high expression in the two weeks after birth. Haass’s group at Ludwig Maximilian University got onto the trail of myelin when they established a developmental profile of BACE-1 expression in the mouse. (Minji Kim, Alice Lu, and Rudy Tanzi first mentioned this work in their report of this spring's Keystone meeting. Here’s the gist of the story, hot off the tail-end of the conference, which concluded yesterday here in Madrid, Spain. Now it turns out that BACE-1 signals Schwann cells to ensheath motoneurons in a developmental period of intense myelination after birth. This aspartyl protease has for years been considered an ideal drug target that appeared to do little else of much consequence other than cleave APP to yield the Aβ peptide BACE-1.
Among their conclusions, they noted the imbalance between training, the updating of knowledge, and specialisation in the footwear sector the difficulty in standardizing the different training levels the lack of teaching resources the need for software teachers to have close contact with the footwear industry and the Icad 3D+ company, and the production of content with the aim of creating knowledge so that future professionals will be able to deal with European and global trends in the footwear industry with creativity, innovation and the latest technologies.ĭuring the INGA 3D project’s next meeting, which will take place in February 2015 in Oporto, Portugal, new goals will be set for the coming year.By the wholly unscientific survey of a roving reporter, the single most convincing and surprising molecular biology story that stuck in the minds of scientists at the 10th ICAD meeting was Christian Haass’s demonstration of a physiological function for the β-secretase BACE-1. The participating partners have analysed the training programs for footwear design in force in Romania, the United Kingdom, Spain and Portugal with the aim of establishing a common framework of knowledge and abilities that the teachers of the Icad 3D+ software must acquire. Moreover, it is intended that the theoretical content will be accompanied by videos and images to demonstrate the operation of the Icad 3D+ software in an intuitive way, always with the aim of guaranteeing the balance of the content, combining theory and practical exercises. In November and December, simulations were performed in order to check the functioning and future interaction between students and teachers. The final structure of the practical portion and the first theory classes are already finished and available on the web, although access is reserved to the project’s partners. The online platform will be available in four languages: English, Spanish, Rumanian and Portuguese.
In recent months the project’s partners have developed the tools that will accompany the learning of the Icad 3D+ software: a manual on designing footwear using 3D CAD, multimedia tools for teachers and tutors of professional training, and an online platform. The INGA 3D project, which brings together the IED Madrid, the Iasi Gheorghe Asachi Technical University, Salford University, Inescop, Virtual Campus and Red21, continues to advance in the development of training for teachers and professionals in footwear.